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To determine the effect of SIRT3 on epigenetic regulation beyond HSCs, we performed single-nuclei ATAC-sequencing of lineage-negative cells from 2-year-old Mx1-Cre and Mx1-T3 mice using the 10x Genomics Chromium platform

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Prior to 2014, effective treatments were extremely limited, and lung transplantation was the primary management option

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