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It has been reported that as GBM progresses to later stages of malignancy, MDMs increasingly replace microglia, becoming the dominant cell type and mediating immune suppression associated with the M2 phenotype

doi: 10.1152/ajpgi.00157.2012

Poomthavorn et al (257) described a cohort of 54 patients with childhood brain injury 4 of whom had known multiple pituitary hormone deficiency prior to the start of the study, in the 50 patients screened however, there were no patients identified with GH deficiency

Since dysregulation within these pathways is frequently associated with organ-specific damage in experimental settings, the data suggest that BPC-157 may support signaling balance by attenuating excessive activation or mitigation within these interconnected systems