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Further studies revealed that Cpd 5 irreversibly inhibits growth-regulatory phosphatase Cdc25 by arylating the cysteine residue of the catalytic site, causing cell cycle arrest [35, 36, 37]
Staphylococcus aureus is the predominant causative agent for osteomyelitis in children 3 and, although the mechanisms are unknown, there is increasing evidence for an association of Panton-Valentine leukocidin (PVL)-expressing S
At steady state, this is an estimate of drug distribution independent of elimination processes
