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Description
Darkness of the skin depends on the concentration of skin pigment Melanin synthesized in the basal level of epidermis
Two possible mechanisms of NO-mediated protein S-glutathionylation can be envisioned: through a GSNO (activated thiol) formation and its consequent reaction with protein-thiol (179) or through an intermediate protein-thiol nitrosylation (activated protein-thiol: analog of sulfenic acid) and its consequent reaction with GSH
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