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Both are major risk factors for micro- and macro-vascular complications, and it may be difficult to differentiate them in risk calculations in clinical trials
About this Chapter As we have seen previously, glucose can be diverted to several different pathways depending on metabolic needs

74,75 Given that the majority of tissues and organs in diabetic patients are affected by hyperglycemia-induced oxidative stress, using natural products with anti-diabetic and antioxidant abilities may have several positive impacts

Pitcher JA, Freedman NJ, Lefkowitz RJ (1998) G protein-coupled receptor kinases
