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4 Adult growth hormone deficiency treatment with a combination of growth hormone and insulin-like growthfactor-1 resulting in elevated sustainable insulin-like growth factor binding protein 3 plasma levels. National Center for Biotechnology Information

Cdrowska E, Pruszyski M, Gawda W, uk M, Krysiski P, Bruchertseifer F, Morgenstern A, Karageorgou M-A, Bouziotis P, Bilewicz A

The neurovascular unit uncoupling initiates glial activation, neuronal apoptosis, blood-retinal barrier leakage, and ischemia, shifting the understanding of DR from a solely vascular disorder to a neurovascular one where early NVU impairment predicts functional deficits like reduced contrast sensitivity and progression to vision-threatening complications (34)

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