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Collagen is the most abundant protein in the body, but production declines as we age, causing dryness and wrinkling of the skin

[PMC free article: PMC4238968] [PubMed: 24563502] 512

Given its critical importance, vitamin B9 deficiency is associated with severe neurological complications, such as spinal cord and peripheral nerve disease, dementia, organic brain syndrome, and pyramidal tract damage (, , )

Different signals activate specific sensory proteins, initiating the assembly of distinct PANoptosome complexes