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Pregnant or breastfeeding

Reduced levels of zinc can impair the pancreass ability to synthesize and secrete insulin and diminish the uptake of glucose by peripheral cells, leading to the development of insulin resistance, a hallmark of diabetes mellitus [5]

Mutations in the MTHFR gene results in a form of homocysteinemia that is often referred to as hyperhomocysteinemia

The early cancer therapies referred to antimetabolites, such as methotrexate (a folate analog) and 5-FU (a pyrimidine analog), that competitively inhibit key metabolic enzymes (e.g., dihydrofolate reductase and thymidylate synthase) in in vivo , thereby affecting or antagonizing cancer cell metabolism and proliferation (Lukey et al., 2017)