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Distribution of cystine/glutamate exchange transporter, system x(c)-, in the mouse brain

Within the ER, hexose-6-phosphate dehydrogenase converts glucose-6-phosphate and NADP + to 6-phosphogluconate and NADPH in a single step, whereas this process in the cytosol requires two separate enzymes (G6PD and PGLS)

As a consequence of high levels relative to other organs, ALT is considered more specific to the liver than AST