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Silybin can counteract this by activating the deacetylase SIRT2 (likely through increasing intracellular NAD+ levels via downregulating PARP-1 expression)
[DOI] [PubMed] [Google Scholar] Collins LJ, Schnfeld B, Chen XS

A treatment must be validated by rigorous studies demonstrating its superiority over placebo to be considered effective

Int J Nephrol Kidney Fail
