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Description
Gastrointest Endosc 2006;63:570-80
By blocking NNMT, 5-Amino-1MQ restores NAD+ availability, reactivates SIRT1-mediated mitochondrial biogenesis, and shifts substrate preference from glucose storage to lipid catabolism
It can also help with sciatica (nerve pain in the lower back and legs) and diabetic neuropathy (diabetes-related nerve pain throughout the body)
The authors were also able to show that CD38 inhibition in vivo had a beneficial effect on controlling LCMV infection in BXD2 lupus-prone mice (30, 37)
