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The primary mechanism that precipitates sepsis is inflammation (4), which generally manifests in two phases: a pro-inflammatory phase, termed systemic inflammatory response syndrome (SIRS), and an anti-inflammatory phase, designated as compensatory anti-inflammatory response syndrome (CARS) (5)

Trained immunity: A memory for innate host defense
PE-AA is then oxidized by lipoxygenases (LOXs), leading to ROS production and lipid peroxidation [54]

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