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doi: 10.1096/fj.202002348R

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For HIF transcription factors, this occurs by hydroxylation at conserved proline residues by prolyl hydroxylases under normoxia, allowing their recognition and ubiquitination by the VHL E3 ubiquitin ligase, which targets HIFs for proteasomal degradation

Additionally, it is widely recognized that nanoparticles smaller than 500 nm can evade the reticuloendothelial system (RES), thereby prolonging their circulation time 47