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Phosphoenolpyruvate is a metabolic checkpoint of anti-tumor T cell responses

Accordingly, the physiological functions of the BBB are gradually being understood

For example, the mechanosensitive ion channel Piezo1 is markedly upregulated in the colonic mucosa of patients with UC (Zhou et al., 2025a), and its excessive activation exacerbates epithelial injury, in part by promoting ferroptosis (He H

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