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[DOI] [PubMed] [Google Scholar] 51.Tesoriere L., Fazzari M., Angileri F., Gentile C., Livrea M.A

A physician-supervised protocol that takes muscle preservation seriously addresses it through three non-negotiable pillars: Protein : approximately 1 g per pound of lean body mass daily, maintained consistently even when appetite is significantly suppressed Branched-chain amino acids : leucine in particular directly suppresses catabolism signalling at the source rather than just providing substrate

These are seen in several other types of EDS as well, typically in classical EDS

There is no published evidence base for cycles longer than 24 weeks, so any extended use is unsupported by trial data
