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however, it is focused on platinum toxicity over primary sensory neurons at the dorsal root ganglia (DRG) [7]
Among them, cathepsin B is thought to bind to NLRP3, thus activating the NLRP3 inflammasome
Individuals with ASD suffer from many gastrointestinal system complaints such as bloating, abdominal pain, constipation, chronic diarrhea, leaky gut syndrome and gastroesophageal reflux [17]
However, the increased oxidative stress that contributed to ASD onset and/or development is reasonable since considerable data suggests beneficial effects of antioxidants in ASD, both from clinical and preclinical studies
