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Description
Patients who experience significant GI side effects may need to delay dose escalation

Proteomic analysis of extracellular vesicles containing damaged mtDNA has revealed that the TLR4 activator ribosomal protein S3 is a key protein involved in recognizing damaged mtDNA [263]

Cytochrome c oxidase deficiency due to a novel SCO2 mutation mimics Werdnig-Hoffmann disease

While these studies were open-label and lacked a placebo control groupa notable clinical limitationthe sheer magnitude of the symptomatic improvement strongly supports the hypothesis that D-Ribose addresses a core bioenergetic deficit in these patient populations
