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Note honestly that human-interest senolytic dosing is typically pulsed/intermittent (a few consecutive days per cycle), so this continuous once-daily-for-16-weeks schedule diverges from the typical senolytic paradigm

Indeed, treatment with a tumor-targeting IL-21 fusion protein expanded cytokine-producing PD1 Int Tim-3 neg CD8 + T cells resulting in tumor control 151 and IL-21 combined with CTLA-4 may have beneficial effects in patients 152