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For example, a translational study showed that ALDH2 suppression was protected by physiologically relevant levels of omega-3 polyunsaturated fatty acids [103, 211], and in a recent phase II clinical trial, treatment with clomethiazole (CMZ), an inhibitor of CYP2E1, mitigated the biomarkers of alcohol-induced oxidative stress and ALD progression [212]
Results Protection from oxidative damage and environmental stress

Muralidharan P, Mallory EK, Malapit M, Phan H, Ledford JG, Hayes D, et al

To address these challenges and elevate oridonins therapeutic potential, we opted for liposomes comprising maleimide polyethylene glycol (PEG) for nano-delivery [30, 31]
