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Animals were lysed by freezing/thawing and extracted using the Bligh and Dyer method 80
Additionally, in another Phase II study targeting patients with T2DM, orforglipron also showed significant effects in reducing A1C and weight, achieving the studys primary and secondary endpoints
however, the overexpression of a CPY * with mutated cysteine residues does not lead to the same increased production of ROS
