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This mutated NOTCH1 is characterized by an extended half-life of the NICD, prolonged NF-B activity, and sustained transcription of genes involved in cell survival and proliferation [15,16,17,18]

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Palmitoyl Dipeptide Peptide that improves collagen production and strengthens the dermal epidermal junction (DEJ) to improve skins structural strength

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A summary of this interaction is shown in Table 3

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Ortega-Domnguez et al., 2017)

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