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Chronic hyperglycemia can cause macrovascular complications such as coronary artery disease, peripheral vascular disease, and cerebrovascular disease, and microvascular complications, including retinopathy, nephropathy, and neuropathy [7]

These findings highlight the inhibitory potential of plant-derived compounds against human GSTs and underscore the importance of investigating phytohormones as possible modulators of hp GSTP1-1 activity

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However, direct epidemiological evidence linking selenium to hearing loss and tinnitus is less consistent than that of lead and cadmium, potentially because blood selenium levels strongly influence its effects