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Nat Immunol (2015) 16(4):34353.10.1038/ni.3123 11 PachecoARBarileDUnderwoodMAMillsDA

However, caution should be exercised when using CBD concurrently with drugs that influence cardiac repolarization or impair drug metabolism, as well as in certain pathophysiological situations, such as hypokalemia, channelopathies, diabetes mellitus, hypertrophic myocardiopathy, or heart failure, among others, CBD can have an additive effect, further increasing the proarrhythmic risk and the possible incidence of sudden cardiac death (Figure 5)

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