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In the field of precise targeted delivery, the bionanosystem AM@HMPB@E demonstrates precise colon lesion targeting capability through the integration of Prussian blue nanozyme (HMPB), entinostat, and AKM, leveraging their combined electrostatic adsorption and bioadhesive properties

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In addition, VEGFR-2 signaling has been shown to lead to Rho/ROCK activation which then affects downstream enzymes such as focal adhesion kinase (FAK) and transcription factors such as signal transducer and activator of transcription (STAT) (30, 223, 224)