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The G-protein G 13 but not G 12 mediates signaling from lysophosphatidic acid receptor via epidermal growth factor receptor to Rho J Biol Chem 273: 46534659, [PubMed] DOI: Cechin, SR, Dunkley, PR and Rodnight, R (2005)

Previous reports suggest that increased hypothalamic mTOR regulation and ribosomal translation increase satiety to reduce food intake in mice 49

established a direct neurotoxic action by acetaminophen both in vitro and in vivo in rats at doses below those required to produce hepatotoxicity and suggested that this neurotoxicity might be involved in the general toxic syndrome observed during patient acetaminophen overdose and, possibly, when acetaminophen doses in the upper dosing schedule are used, especially if other risk factors (moderate alcohol drinking, fasting, nutritional impairment) are present