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Br J Rheumatol 1994;33(8):745-8

Vascular calcification and advanced glycation end products, or AGEs, provide additional pathways through which arteries may become less flexible

55 Apart from the calcium-dependent eNOS activation, exercise also stimulates hormone and growth factor secretions such as norepinephrine (NE) and vascular endothelial growth factor (VEGF), which may bind to 3-AR and VEGFR in endothelial cells and further activate PI3K/AKT signaling and subsequent eNOS phosphorylation

Acute signaling responses occur within hours to days, protein synthesis changes manifest over days to weeks, and structural adaptations like muscle hypertrophy need weeks to months