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The Prohibited List is broken down into three parts: If a substance or method is on or is added to the List, it meets at least two of the following three criteria: Of the substances and methods prohibited at all times , there are six substance categories: S0 (non-approved substances), S1 (anabolic agents), S2 (peptide hormones, growth factors, related substances and mimetics), S3 (beta-2 agonists), S4 (hormone and metabolic modulators) and S5 (diuretics and masking agents)