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The inability to histologically analyze the entire specimen is also a concern, given the prevalence of invasive melanoma in 8.1 to 16 percent of tumors initially diagnosed as LM [47, 48]

This occurs due to a flaw in the transport system, specifically in the OCTN2 transporter (which moves carnitine into cells) that is determined by the SLC22A5 gene

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In a state of mitochondrial dysfunction, partially metabolized fatty acids can build up inside the mitochondria, forming toxic acyl-CoA compounds that inhibit essential enzymes and cause severe oxidative stress