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Therefore, in order to investigate the importance of GSH under metal stress, GSH-deficient conditions in mutants due to decreased GSH1 activity are preferred instead of knockout plants [23]

Compartment-targeted HyPer to track H 2 O 2 in matrix/ER/nucleus) with damage footprints (F 2 -isoprostanes, nitrotyrosine, protein carbonyls, 8-oxoG) and iron metrics (calcein-quench assays of the labile iron pool with chelator validation, ferritin, HO-1 and ferritinophagy markers) and that are interpreted with strict source attribution and compartment awareness (Murphy et al

Neuroscience 144 : 9911003 (2007)