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Together, these results indicate that decreased GSH/GSSG redox/antioxidant capacity and increased oxidative stress in the autism brain may have functional consequence in terms of a chronic inflammatory response, increased mitochondrial superoxide production, and oxidative protein and DNA damage.
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Meanwhile, the activities of glutathione reductase (GR) and superoxide dismutase (SOD) enzymes were also enhanced after APP treatment, while the catalase (CAT) activity decreased
