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Systemic PF4 attenuates age-related inflammatory signatures and rescues cognition in aged mice [318], whereas klotho elevates platelet factors, including PF4, to enhance cognition across age groups [319]
Epigenetic changes Changes in phenotype that are driven by changes in the regulation of gene expression or changes in the function of gene products rather than by a change in genotype
References 1.Su D, Cui Y, He C, Yin P, Bai R, Zhu J, et al
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