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We can only speculate that omega-3 FA exerts their antidepressant effect, except for other mechanisms ( No correlation was found between the studied metabolites of TRP degradation and the concentrations of EPA and DHA FAs determined in the same cohort of patients ( Figure 1 )

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347,348 High glucose levels inhibit the PI3K/Akt pathway in Schwann cells, leading to overexpression of DNA methyltransferases (DNMT1 and DNMT3a) and upregulation of thioredoxin-interacting protein (TXNIP)