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Activated glial cells can lead to oxidative stress, and excessive oxygen free radicals damage the cell membrane, mitochondria, and DNA, thus exacerbating the inflammatory response and even leading to neuronal damage and death
Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature. Journal of Neuropathology and Experimental Neurology 71: 362381
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There may also be bright spots at the macula
