Antidotes in Pharmacology
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Description
2024;80:228.e221-228.e224
Targeting specific signaling pathways, such as JAK/STAT, PI3K/AKT, and NF-B, which regulate TAM polarization, along with innovative strategies like nanocarriers, exosomes, and CAR-macrophage therapy, could significantly improve the efficacy of cancer treatments, particularly in solid tumors where immunosuppression is a major challenge (155)
The study revealed significant reductions in disease severity, achieved by downregulating the secretion of ulcerative biomarkers and enhancing endogenous antioxidant markers in nude mice treated with DSS
Nat Rev Microbiol 15(5):271284
