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It inhibits iron-dependent cell death, known as ferroptosis, which leads to damage and disorganization of the cell membrane [71,74]

doi: 10.1007/s10059-012-0048-8

Body iron stores and their determinants in healthy postmenopausal US women

In vitro studies showed that the neutral charge state of the surface of ZIF-8@Hb surface significantly enhanced stability in alkaline, oxidative, elevated temperature, or enzymatic environments, which is favorable for long-term blood circulation (as the study found that the blood circulation half-life (t1/2) of ZIF-8@Hb was 13.9 h, compared to 1.4 and 5.1 h for ZIF-8 and Hb, respectively)