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8-OHdG can be measured in the plasma, semen, and urine and has been shown to be significantly higher in infertile men than in fertile men [42]

This supports that the DNA damage effect was mediated by the ROS produced during the redox cycling process to form hydroxylated and other altered DNA products, which was determined by 32P DNA radiolabelling and two-dimensional thin-layer chromatography [68]

Experimental models frequently employ the natural neurotoxin kainic acid to trigger excitotoxic neuronal death, providing a well-established paradigm for studying neurodegeneration [98]

In contrast, physiological hypoxia may manifest in healthy individuals residing at high altitudes (Reference Lenfant, Torrance and English93,Reference Eaton, Brewer and Grover94)