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Successful drug discovery requires continuous focus on basic and translational methods to fully elucidate the etiologies of this disease to enable the development of targeted therapies

Cysteine deserves particular emphasis: its thiol undergoes SN2 alkylation, Michael addition, disulfide bond formation and exchange, and graded oxidation by hydrogen peroxide to form sulfinic and sulfonic acids

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For example, transcription factors play an important role in regulating transcription by binding to specific recognition sites on the chromosome, often at a genes promoter, and interacting with other proteins in the nucleus