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In addition, ZIP8-knockout mice display impaired iron recycling during inflammation, elevated splenic iron and reduced serum iron, highlighting ZIP8s role in systemic metal handling 175

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Overexpression of Igfbp-1 in transgenic mice using either a phosphogylcerate kinase [73] or a methallothionein [74] promoter results in similar phenotypes as observed in adult Igf-1-deficient mice: reduced brain sizes due to loss of mature neurons and decreased progenitor proliferation, impaired myelination as well as decreased activation of GFAP-expressing astrocytes in conditions of injury