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The most commonly utilized chemotherapy drug in OS treatment is cisplatin (DDP)

These bacteria ferment inulin into butyrate, which inhibits the phosphorylation of Nuclear Factor kappa-B (NF-B) p65 in colonic epithelial cells, thereby reducing the secretion of pro-inflammatory cytokines such as IL-6 and TNF- (44, 132)

10.1519/JSC.0000000000001437 70 NaseemK

3.2.2 Transient receptor potential Channels (TRP) TRP channels are the largest receptor family involved in detecting noxious stimuli and play a pivotal role as targets in the development of new analgesics
