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[DOI] [PubMed] [Google Scholar] 101.Sorbara M.T., Dubin K., Littmann E.R., Moody T.U., Fontana E., Seok R., Leiner I.M., Taur Y., Peled J.U., van den Brink M.R.M., et al
The CNS compartments are tightly sealed from the changeable milieu of blood by the BBB as well as the bloodCSF barrier (BCSFB)

Under physiological conditions, ERAD and the UPR cooperate to maintain proteostasis by ensuring proper folding, processing, and clearance of secretory and membrane proteins
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