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For the 4 mg dose, there was no significant difference compared to the placebo group, with an RR of 1.11 (95% CI: 0.93 to 1.31, P = 0.24)

Despite their potential, polyphenols remain underutilized in functional foods and dietary supplements due to several physicochemical properties, including low epithelial permeability, poor solubility in gastrointestinal fluids, structural modifications during digestion, and limited oral bio-accessibility (128, 129)