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The high reactivity of HNE results from the diminished electron density around carbon-3 of HNE as a consequence of two factors: 1 ) the resonance between the C=C of carbons-2 and -3 and the C=O bond of the aldehyde functional group on carbon-1 and 2 ) the inductive effect of the more electronegative O atom on the OH group of carbon-4 with the electrons around carbon-3

doi: 10.3760/cma.j.cn121430-20220809-00731 107 WuTJWangSHChenESTsaiHHChangYCTsengYHet al

Conserved region 3 (CR3) of human FOXO4 was similarly modelled by I-TASSER using the NMR structure of the CR3 domain of FOXO3 (PDB ID: 2LQH) [20] as the template

Serum glucose and insulin levels in normotensive (WKY) and spontaneously hypertensive (SH) rats during and after the cessation of continuous (10 day) clonidine infusion