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Heinz bodies are formed by damage to the hemoglobin component through oxidative damage by administered drugs, or from an inherited mutation

Interestingly, this protein also accounts for dehydroascorbic acid transport through the erythrocyte membrane [183]
Treating sickle cell anemia: a new era dawns

(B) In CKD, uremic toxins (UT), such as indoxyl sulfate (IS) accumulate
