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Notably, the aged cortex produced a more extensive effect on graft connectivity than the cortex of 8-month-old APP/PS1 transgenic mice, despite exhibiting greater inter-individual variability (Thomas et al., 2022)
However, it is important to note here that one study conflicted with this evidence and investigators observed agonist-induced desensitization of the 2C -AR receptor in opossum kidney cells overexpressing GRK
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