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& Gao, H

Preclinical: With increased knowledge of the nose-brain pathway and IN therapeutics, IN-BDNF to mouse models of depression is being explored: in a chronic mild stress (CMS) induced-depression model, mice were given AAV-packaged BDNF fused with cell-penetrating peptides, human immunodeficiency virus-1 transactivator of transcription (TAT), and influenza A hemagglutinin glycoprotein 2 (HA2)

Cardiac lesion estimation was based on the dilatation and congestion of blood vessels within the myocardium and coronary arteries using a scale ranging 03 (0: none

For more extensive revisions, initial recovery typically takes one to two weeks, while complete healing and scar maturation can take several months