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As immunotherapeutic sensitivity increases (from nonresponder to pCR), apCAFs co-localized with macrophages (mostly SELENOP-macrophages), accumulated in tumor boundaries and infiltrated within tumor regions, indicating the cooperative roles of apCAFs and SELENOP-macrophages in the anti-tumor activity induced by immunotherapy

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A recently described example in which a glutathione S -conjugate is formed by Michael addition across a reactive double bond followed by reversible cysteine S -conjugate formation involves (6)-shogaol

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