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Key pathways include TGF-beta superfamily signaling, ubiquitin-proteasome components, DNA repair enzymes, and antioxidant response genes (SOD, catalase)

Disruption of the glucagon receptor increases glucagon expression and granule populations in cells Our previous studies have shown that GCGR deficiency increases glucagon expression in zebrafish cells 16

[DOI] [PubMed] [Google Scholar] 2
