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In particular, Cao and colleagues conducted a prospective cohort study (NCT00835341) to evaluate the predictive value of p16 methylation in patients diagnosed with oral epithelial dysplasia, demonstrating that the progression rates to OC were significantly higher in patients with p16 promoter hypermethylation compared to those with unmethylated p16 [278]
doi:10.1016/0003-2697(79)90720-6
Normotensive age-matched PTCs ( n = 30) were selected based on the absence of placental disease with appropriate-for-gestational-age foetuses
