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Peer review Peer review information Nature Communications thanks Mary Playdon and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

As routine COVID-19 treatments included anticoagulant therapy and participants were at risk for bleeding, we daily tested participants venous blood gas instead of arterial blood gas testing

Data so far obtained from this study would suggest that administration of l-carnitine after MTX challenge may have beneficial effects that could possibly be ascribed, in part, to its regulation of the oxidant/anti-oxidant balance