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Winter conditions like cold air, low humidity, indoor heating, and hot showers can strip natural oils and compromise your skin barrier
Thus, the impaired expression of lipid-regulating genes appears to have a significant impact on the etiology of OA by contributing to lipid buildup and its negative effects on cartilage health ( The synovium consists of macrophages, fibroblasts, and endothelial cells ( IL-1 and TNF- , which generate MMPs and inhibit the production of collagen and proteoglycan, leading to low-grade synovitis ( Figure 1 )

Curr Probl Cardiol 47:101213

With respect to chemotype determination, the method consists of assigning an ID number to the six major kavalactones according to their elution order in HPLC (Table 2) and analyzing their percent content [3,43,44]
